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Our Pipeline

 Tissue-intelligent Medicines 

 

  1. OA Action Alliance. Access www.oaaction.unc.edu​
  2. Osteoarthritis Research Society International (OARSI). Osteoarthritis: a serious disease. White paper submitted to the U.S. FDA; 2016. Accessed at www.oarsi.org ​
  3. Bliddal H, et al. New Engl J Med, 2024: 391(17)​
  4. Wylde V, et al, Pain, 2011: 152 (3)​
  5. Wood MJ, et al. JCI Insight. 2019: 4​
  6. Martel-Pelletier J, et al. Nat Rev Dis Primers. 2016: 2 ​
  7. Robinson WH, et al. Nat Rev Rheumatol. 2016: 12​
  8. Scanzello CR, Goldring SR. Bone. 2012: 51 ​
  9. Berenbaum F, Osteoarthritis Cartilage. 2013: 21​
  10. Schieker M, Conaghan PG, et al. Annals of Internal Medicine, 2020   ​
  11. Ridker PM, et al. New Engl J Med, 2017: 377(12)  (main CANTOS publication) ​
  12. Zhu Y, et al, Arthritis Rheum. 2011: 63 ​
  13. Kuo CF, et al, Nat Rev Rheumatology, 2015: 11​
  14. Lim SY, et al, JAMA. 2016: 315. ​
  15. Wu EQ, et al, J Manag Care Pharm. 2008: 14​
  16. Ruoff G, et al, Postgrad. Med. 2016: 128​
  17. Schlesinger N, et al, J. Rheumatol. 2009: 36​
  18. Terkeltaub, R, et al, Arthritis Res. Ther. 2006: 8, S4 ​
  19. Schlesinger N, et al, Nature Rev. Rheumatology, 2023: 19​
  20. Solomon DH, et al. Annals of Internal Medicine, 2018: 169 (8)


Rigorous Science & Execution

Leveraging unmatched scientific expertise & strong collaborations  with leading biotechnology centers of excellence 


Derisked mechanisms, tissue-intelligence & long-acting proprietary biologics 

Harnessing novel multi-parameter & computational optimization tools for structure-guided precision medicine

Reliable, cost-effective & scalable CMC manufacturing platform

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